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kuhusu 500000~10000000

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yRetractionShortNoteStudyProtocolSystematicReviewTechnicalNoteTutorialViewpoint  AdvancedSearch SectionSpecialIssueVolumeIssueNumberPe LogicalOperatorOperatorANDORSearchTextSearchTypeAllfieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFullTextReferences add_circle_outlineremove_circle_outline  SustainabilityFormation,Characteristics,andInfluencingFactorsofthePlastisphereBiomedicinesTheInfluenceofCross-ReactiveTCellsinCOVID-19SensorsHardSyDR:ABenchmarkingEnvironmentforGNSSAlgorithmsMicromachinesAReviewonMachiningSiCp/AlCompositeMaterialsRecentArticles 18pes,KiB OpenAccessArticleA5KEfficientLow-LightEnhancementModelbyEstimatingIncrementbetweenDarkImeandTransmissionMapBasedonLocalMaximumColorValuePriorbyQikangDeng,DongwonChoo,HyochulJiandDohoonLeeElectronics2024,13(10),1814;doi.org/10.3390/electronics(registering DOI)-08May2024AbstractLow-lightenhancement(LLE)hasseensignificantadvancementsoverdecades,leadingtosubstantialimprovementsinimequalitythatevensurpassgroundtruth.However,theseadvancementshecomewithadownsideasthemodelsgrewinsizeandcomplexity,losingtheirlightweightandreal-timecapabilities[...]Readmore.Low-lightenhancement(LLE)hasseensignificantadvancementsoverdecades,leadingtosubstantialimprovementsinimequalitythatevensurpassgroundtruth.However,theseadvancementshecomewithadownsideasthemodelsgrewinsizeandcomplexity,losingtheirlightweightandreal-timecapabilitiescrucialforapplicationslikesurveillance,autonomousdriving,smartphones,andunmannedaerialvehicles(Us).Toaddressthischallenge,weproposeanexceptionallylightweightmodelwithjustaround5Kparameters,whichiscapableofdeliveringhigh-qualityLLEresults.Ourmethodfocusesonestimatingtheincrementalchangesfromdarkimestotransmissionmapsbasedonthelowmaximumcolorvalueprior,andweintroduceanovelthree-channeltransmissionmaptocapturemoredetailsandinformationcomparedtothetraditionalone-channeltransmissionmap.Thisinnovativedesignallowsformoreeffectivematchingofincrementalestimationresults,enablingdistincttransmissionadjustmentstobeappliedtotheR,G,andBchannelsoftheime.Thisstreamlinedapproachensuresthatourmodelremainslightweight,makingitsuitablefordeploymentonlow-performancedeviceswithoutcompromisingreal-timeperformance.Ourexperimentsconfirmtheeffectivenessofourmodel,achievinghigh-qualityLLEcomparabletotheIAT(local)model.Impressively,ourmodelachievesthislevelofperformancewhileutilizingonly0.512GFLOPsand4.7Kparameters,representingjust39.1%oftheGFLOPsand23.5%oftheparametersusedbytheIAT(local)model.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancedTheoriesandApplicationsofMultimediaInformationTechnology(InvitedPapersfromMITA2023))9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure922pes,1558KiB OpenAccessArticlePrimingofPossessiveConstructionsinGerman:AMatterofPreferenceEffects?bySarahSchimkeandSandraPappertLangues2024,9(5),170;doi.org/10.3390/langues(registering DOI)-08May2024AbstractWeinvestigatedstructuralpriminginadultnativespeakers,focusingonpossessiveconstructionsinGerman,wherethetwoalternativestructuresinvolveddifferinfrequency.Accordingtoerror-basedlearningapproachestopriming,thelessfrequentstructureshouldleadtoalargerpredictionerrorandlarger[...]Readmore.Weinvestigatedstructuralpriminginadultnativespeakers,focusingonpossessiveconstructionsinGerman,wherethetwoalternativestructuresinvolveddifferinfrequency.Accordingtoerror-basedlearningapproachestopriming,thelessfrequentstructureshouldleadtoalargerpredictionerrorandlargerprimingeffectsthanthemorefrequentstructure.Inacomparisonofpreferencesduringapretestandpreferencesduringpriming,wedidnotfindevidenceofsuchaninversepreferenceeffect.Moreover,duringpriming,weobservedincreasingproductionratesofthepreferredstructure,hence,acumulativeprimingeffect.Inlinewithhybridmodelsofpriming,weproposethattwomechanisms,namely,amechanismlearningfrominputaswellasamechanismaccumulatingactivationduringcomprehensionandproduction,areinvolvedinthetemporaldevelopmentofprimingeffects.Moreover,wesuggestthattheinteractionofthetwomechanismsmaydependonpriorexperiencewiththealternativestructures.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinSyntacticAdaptation)9658;9660;ShowFiguresFigure1Figure1Cont.---Figure2---Figure3---FigureA1---FigureA225pes,KiB OpenAccessArticleDay-to-NightStreetViewImeGenerationfor24-HourUrbanSceneAuditingUsingGenerativeAIbyZhiyiLiu,TingtingLi,TianyiRen,DaChen,WenjingLiandWaishanQiuJ.Iming2024,10(5),112;doi.org/10.3390/jiming(registering DOI)-07May2024AbstractAsmartercityshouldbeasafercity.Nighttimesafetyinmetropolitanareashaslongbeenaglobalconcern,particularlyforlargecitieswithdiversedemographicsandintricateurbanforms,whosecitizensareoftenthreatenedbyhigherstreet-levelcrimerates.However,dueto[...]Readmore.Asmartercityshouldbeasafercity.Nighttimesafetyinmetropolitanareashaslongbeenaglobalconcern,particularlyforlargecitieswithdiversedemographicsandintricateurbanforms,whosecitizensareoftenthreatenedbyhigherstreet-levelcrimerates.However,duetothelackofnight-timeurbanappearancedata,priorstudiesbasedonstreetviewimery(SVI)rarelyaddressedtheperceivednight-timesafetyissue,whichcangenerateimportantimplicationsforcrimeprevention.Thisstudyhypothesizesthatnight-timeSVIcanbeeffectivelygeneratedfromwidelyexistingdaytimeSVIsusinggenerativeAI(GenAI).Totestthehypothesis,thisstudyfirstcollectspairwiseday-and-nightSVIsacrossfourcitiesdivergedinurbanlandscapestoconstructacomprehensiveday-and-nightSVIdataset.Itthentrainsandvalidatesaday-to-night(D2N)modelwithfine-tunedbrightnessadjustment,effectivelytransformingdaytimeSVIstonighttimeonesfordistincturbanformstailoredforurbansceneperceptionstudies.Ourfindingsindicatethat:(1)theperformanceofD2Ntransformationvariessignificantlybyurban-scapevariationsrelatedtourbandensity;(2)theproportionofbuildingandskyviewsareimportantdeterminantsoftransformationaccuracy;(3)withinprevailedmodels,CycleGANmaintainstheconsistencyofD2Nsceneconversion,butrequiresabundantdata.Pix2Pixachievesconsiderableaccuracywhenpairwiseday–and–night-nightSVIsareailableandaresensitivetodataquality.StableDiffusionyieldshigh-qualityimeswithexpensivetrainingcosts.Therefore,CycleGANismosteffectiveinbalancingtheaccuracy,datarequirement,andcost.Thisstudycontributestourbanscenestudiesbyconstructingafirst-of-its-kindD2Ndatasetconsistingofpairwiseday-and-nightSVIsacrossvariousurbanforms.TheD2NgeneratorwillprovideacornerstoneforfutureurbanstudiesthatheilyutilizeSVIstoauditurbanenvironments.Fullarticle(ThisarticlebelongstotheSpecialIssueVisualLocalization—VolumeII)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure10Cont.---FigureA116pes,1661KiB OpenAccessArticleUtilizationofMentalHealthProvision,EpistemicStanceandComorbidPsychopathologyofIndividualswithComplexPost-TraumaticStressDisorders(CPTSD)—ResultsfromaRepresentativeGermanObservationalStudybyDidRiedl,HannaKampling,TobiasNolte,ChristinaKirchhoff,JohannesKruse,CedricSachser,JörgM.Fegert,HaraldGündel,ElmarBrähler,VincentGrote,MichaelJ.FischerandAstridLampeJ.Clin.Med.2024,13(10),2735;doi.org/10.3390/jcm-07May2024AbstractBackground:Complexpost-traumaticstressdisorder(CPTSD)isaseverelydebilitatingrecentlyaddedsymptomclusterintheInternationalClassificationofDiseases(ICD-11).Sofar,onlylimitedinformationonmentalhealthtreatment-uptakeand-satisfactionofindividualswithCPTSDisailable.Theaimofthis[...]Readmore.Background:Complexpost-traumaticstressdisorder(CPTSD)isaseverelydebilitatingrecentlyaddedsymptomclusterintheInternationalClassificationofDiseases(ICD-11).Sofar,onlylimitedinformationonmentalhealthtreatment-uptakeand-satisfactionofindividualswithCPTSDisailable.TheaimofthisstudyistoinvestigatetheseaspectsinarepresentativesampleoftheGermangeneralpopulation.Methods:ParticipantscompletedtheInternationalTraumaQuestionnaire(ITQ)toidentifyparticipantswithCPTSD,aswellasquestionnairesonmentalhealthtreatmentuptakeandsatisfaction,adversechildhoodexperiences,anxiety,depression,workingability,personalityfunctioning,andepistemictrust.Results:Oftheincludedn=1918participants,n=29(1.5%)fulfilledthecriteriaforCPTSD.ParticipantswithCPTSDhadreceivedmentalhealthtreatmentsignificantlymoreoftenthanparticipantswithPTSDordepression(65.5%vs.58.8%vs.31.6%;p=0.031)butreportedsignificantlylesssymptomimprovement(52.9%vs.78.0%vs.80.0%;p=0.008).LowerlevelsofepistemictrustwereassociatedwithhigherCPTSDsymptoms(p<0.001).Conclusions:OurstudyshowsthatwhilethevastmajorityofindividualswithCPTSDhadreceivedmentalhealthtreatment,subjectivesymptomimprovementratesarenotsatisfactory.CPTSDwasassociatedwithabroadnumberofcomorbiditiesandimpairmentsinfunctioning.Lowerlevelsofepistemictrustmaypartiallyexplainworsetreatmentoutcomes.Fullarticle(ThisarticlebelongstotheSectionMentalHealth)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure319pes,3963KiB OpenAccessArticleTheEffectofOrallyAdministeredMulti-StrainProbioticFormulation(Lactobacillus,Bifidobacterium)onthePhocyticActivityandOxidativeMetabolismofPeripheralBloodGranulocytesandMonocytesinLambsbyRomanWójcik,JoannaMałaczewska,DawidTobolski,JanMiciński,EdytaKaczorek-ŁukowskaandGrzegorzZwierzchowskiInt.J.Mol.Sci.2024,25(10),5068;doi.org/10.3390/ijms-07May2024AbstractProbioticfeedadditivesheattractedconsiderableresearchinterestinrecentyearsbecausetheeffectivenessofprobioticscandifferacrossmicrobialstrainsandthesupplementedmacroorganisms.Thepresentstudywasconductedon16lambsdividedequallyintotwogroups(C—controlandE—experimental).Theexamined[...]Readmore.Probioticfeedadditivesheattractedconsiderableresearchinterestinrecentyearsbecausetheeffectivenessofprobioticscandifferacrossmicrobialstrainsandthesupplementedmacroorganisms.Thepresentstudywasconductedon16lambsdividedequallyintotwogroups(C—controlandE—experimental).Theexaminedlambswereed11daysatthebeginningoftheexperimentand40daysattheendoftheexperiment.ThedietofgroupElambswassupplementedwithamulti-strainprobioticformulation(LactobacillusplantarumAMT14,LactobacillusplantarumAMT4,LactobacillusrhamnosusAMT15,andBifidobacteriumanimalisAMT30),whereasgroupClambsdidnotreceivetheprobioticadditive.Atthebeginningoftheexperiment(day0)andonexperimentaldays15and30,bloodwassampledfromthejugularveintodetermineandcompare:phocyticactivity(Photest)andoxidativemetabolism(Phoburst)ofperipheralbloodgranulocytesandmonocytesbyflowcytometry.Ananalysisofthephocyticactivityofgranulocytesandmonocytesrevealedsignificantlyhigherlevelsofphocyticactivity(expressedasthepercenteofphocyticcellsandmeanfluorescenceintensity)inlambsthatwereadministeredthemulti-strainprobioticformulationcomparedwithlambsinthecontrolgroup.Theprobioticfeedadditivealsoexertedapositiveeffectontheoxidativemetabolismofbothgranulocytesandmonocytes(expressedasthepercenteofoxidativemetabolismandmeanfluorescenceintensity)afterstimulationwithEscherichiacolibacteriaandwithPMA(4-phorbol-12-β-myristate-13-acetate).Thesefindingssuggestthatthetestedprobioticformulationmayheapositiveeffectontheimmunestatusoflambs.Fullarticle(ThisarticlebelongstotheSpecialIssuePro-inflammatoryandAnti-inflammatoryInterleukinsinVariousDiseases2.0)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure1117pes,2376KiB OpenAccessArticleCytotoxicEffectofAmyloid-β1-42OligomersonEndoplasmicReticulumandGolgiApparatusArrangementinSH-SY5YNeuroblastomaCellsbyJoséJ.Jarero-Basulto,YadiraGasca-Martínez,MarthaC.Rivera-Cervantes,DeisyGasca-Martínez,NidiaJannetteCarrillo-González,CarlosBeas-ZárateandGracielaGudiño-CabreraNeuroSci2024,5(2),141-157;doi.org/10.3390/neurosci(registering DOI)-07May2024AbstractAmyloid-βoligomersareacytotoxicstructurethatiskeyfortheestablishmentofthebeginningstesofAlzheimer’sdisease(AD).Thesestructurespromotesubcellularalterationsthatcausesynapticdysfunction,lossofcellcommunication,andevencelldeath,generatingcognitivedeficits.Theaimof[...]Readmore.Amyloid-βoligomersareacytotoxicstructurethatiskeyfortheestablishmentofthebeginningstesofAlzheimer’sdisease(AD).Thesestructurespromotesubcellularalterationsthatcausesynapticdysfunction,lossofcellcommunication,andevencelldeath,generatingcognitivedeficits.Theaimofthisstudywastoinvestigatethecytotoxiceffectsofamyloid-β1-42oligomers(AβOs)onthemembranousorganellesinvolvedinproteinprocessing:theendoplasmicreticulum(ER)andGolgiapparatus(GA).Theresultsobtainedwith10μMAβOsinSH-SY5Yneuroblastomacellsshowedthatoligomericstructuresaremoretoxicthanmonomersbecausetheycausecellviabilitytodecreaseasexposuretimeincreases.SurvivorcellswereanalyzedtofurtherunderstandthetoxiceffectsofAβOsonintracellularorganelles.Survivorcellsshowedmorphologicalalterationsassociatedwithabnormalcytoskeletonmodification72–96hafterexposuretoAβOs.Moreover,theERandGApresentedrearrangementthroughoutthecytoplasmicspace,whichcouldbeattributedtoalackofconstitutiveproteinprocessingortopreviousabnormalcytoskeletonmodification.Interestingly,thedisorganizationofbothERandGAorganellesexposedtoAβOsislikelyanearlypathologicalalterationthatcouldberelatedtoaberrantproteinprocessingandaccumulationinAD.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1740KiB)18pes,2212KiB OpenAccessArticleUpregulationofmRNAExpressionofADGRD1/GPR133andADGRG7/GPR128inSARS-CoV-2-InfectedLungAdenocarcinomaCalu-3CellsbySandraŽáčková,MarcelaPávová,JanaTrylčová,JitkaChalupová,AnastasiiaPriss,OndřejLukšanandJanWeberCells2024,13(10),791;doi.org/10.3390/cells(registering DOI)-07May2024AbstractAdhesionGprotein-coupledreceptors(PCRs)playanimportantroleinneurodevelopment,immunedefenceandcancer;however,theirrolethroughoutviralinfectionsismostlyunexplored.WehebeensearchingforspecificPCRsinvolvedinSARS-CoV-2infectionofmammaliancells.Inthepresentstudy,we[...]Readmore.AdhesionGprotein-coupledreceptors(PCRs)playanimportantroleinneurodevelopment,immunedefenceandcancer;however,theirrolethroughoutviralinfectionsismostlyunexplored.WehebeensearchingforspecificPCRsinvolvedinSARS-CoV-2infectionofmammaliancells.Inthepresentstudy,weinfectedhumanepithelialcelllinesderivedfromlungadenocarcinoma(Calu-3)andcolorectalcarcinoma(Caco-2)withSARS-CoV-2inordertoanalysechangesinthelevelofmRNAencodingindividualPCRsat6and12hpostinfection.BasedonsignificantlyalteredmRNAlevels,weidentifiedfourPCRcandidates—ADGRB3/BAI3,ADGRD1/GPR133,ADGRG7/GPR128andADGRV1/GPR98.Ofthesereceptors,ADGRD1/GPR133andADGRG7/GPR128showedthelargestincreaseinmRNAlevelsinSARS-CoV-2-infectedCalu-3cells,whereasnoincreasewasobservedwithheat-inactivatedSARS-CoV-2andvirus-clearedconditionedmedia.Next,usingspecificsiRNA,wedownregulatedthePCRcandidatesandanalysedSARS-CoV-2entry,replicationandinfectivityinbothcelllines.WeobservedasignificantdecreaseintheamountofSARS-CoV-2newlyreleasedintotheculturemediabycellswithdownregulatedADGRD1/GPR133andADGRG7/GPR128.Inaddition,usingaplaqueassay,weobservedareductioninSARS-CoV-2infectivityinCalu-3cells.Insummary,ourdatasuggestthatselectedPCRsmightplayaroleduringSARS-CoV-2infectionofmammaliancells.Fullarticle(ThisarticlebelongstotheSpecialIssueStructures,Regulation,Signaling,andPhysiologicalFunctionsofAdhesionG-ProteinCoupledReceptors)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4attachmentSupplementarymaterial:SupplementaryFile1(ZIP,223KiB)12pes,1649KiB OpenAccessArticleAlterationsinPeripheralLymphocyteSubsetsunderImmunochemotherapyinSteIVSCLCPatients:Th17CellsasPotentialEarlyPredictiveBiomarkerforResponsebyAnn-KristinSchmälter,PhillipLöhr,MaikKonrad,JohannaWaidhauser,TimTobiasArndt,StefanSchiele,AliciaThoma,BjörnHackansonandAndreasRankInt.J.Mol.Sci.2024,25(10),5056;doi.org/10.3390/ijms(registering DOI)-07May2024AbstractUICCsteIVsmall-celllungcancer(SCLC)isahighlygressivemalignancywithoutcurativetreatmentoptions.Severalrandomizedtrialshedemonstratedimprovedsurvivalratesthroughtheadditionofcheckpointinhibitorstofirst-lineplatin-basedchemotherapy.Consequently,acombinationofchemo-andimmunotherapyhasbecome[...]Readmore.UICCsteIVsmall-celllungcancer(SCLC)isahighlygressivemalignancywithoutcurativetreatmentoptions.Severalrandomizedtrialshedemonstratedimprovedsurvivalratesthroughtheadditionofcheckpointinhibitorstofirst-lineplatin-basedchemotherapy.Consequently,acombinationofchemo-andimmunotherapyhasbecomestandardpalliativetreatment.However,noreliablepredictivebiomarkersfortreatmentresponseexist.NeitherPD-L1expressionnortumormutationalburdenheproventobeeffectivepredictivebiomarkers.Inthisstudy,wecomparedthecellularimmunestatusesofSCLCpatientstoahealthycontrolcohortandinvestigatedchangesinperipheralbloodB,T,andNKlymphocytes,aswellasseveraloftheirrespectivesubsets,duringtreatmentwithimmunochemotherapy(ICT)usingflowcytometry.OurfindingsrevealedasignificantdecreaseinBcells,whileTcellsshowedatrendtoincreasethroughoutICT.Notably,highlevelsofexhaustedCD4+andCD8+cells,alongsideNKsubsets,increasedsignificantlyduringtreatment.Furthermore,wecorrelateddecreases/increasesinsubsetsaftertwocyclesofICTwithsurvival.Specifically,adecreaseinTh17cellsindicatedabetteroverallsurvival.Basedonthesefindings,wesuggestconductingfurtherinvestigationintoTh17cellsasapotentialearlypredictivebiomarkersforresponseinpatientsreceivingpalliativeICTforsteIVSCLC.Fullarticle(ThisarticlebelongstotheSpecialIssueImmunophenotypinginAutoimmuneDiseasesandCancer,4thEdition)9658;9660;ShowFiguresFigure1Figure2---Figure316pes,1928KiB OpenAccessArticleComprehensiveEvaluationofDecarbonizationTechnologies:ACaseStudyofResidentialBuildingsinZhuzhouCity,ChinabyJianlongLiu,QingTang,HaiyanChen,WenjingMeng,FengXuandZhishengLiBuildings2024,14(5),1322;doi.org/10.3390/buildings(registering DOI)-07May2024AbstractEfficientcarbonemissionreductiontechnologiesinbuildingsarenecessaryforachievingthe“Dualcarbon”goalinChina.Inthisstudy,acomprehensiveevaluationmodelisproposedtoassesstheeffectofcarbonemissionreductionbasedontheanalytichierarchyprocess–entropyweight–coefficientofvariation[...]Readmore.Efficientcarbonemissionreductiontechnologiesinbuildingsarenecessaryforachievingthe“Dualcarbon”goalinChina.Inthisstudy,acomprehensiveevaluationmodelisproposedtoassesstheeffectofcarbonemissionreductionbasedontheanalytichierarchyprocess–entropyweight–coefficientofvariationmodelwhichtakesnewlybuiltresidentialbuildingsinZhuzhouCityastheresearchobject.Theresultsshowthatthepreferredmaterialsfortheroofandexteriorwallsofthebuilding’senvelopestructurewereflame-retardantextrudedpolystyreneboards,andporousshalebrickswerepreferredasthemainmaterialsfortheexteriorwalls.Inaddition,therooftopsolarphotovoltaicsystemandenergy-singairconditioningtechnologyweresuitableintermsofbeingrenewableandwerebetterutilized.Intheend,carbonemissionsweresignificantlyreducedwhenusingthebuildingdecarbonizationtechnologies.ThisstudyprovidesanewreferenceforchoosingmaterialsandtechnologiesforthedesignofresidentialbuildingsinHunanProvinceandevenotherregionswithhotsummersandcoldwinters.Fullarticle(ThisarticlebelongstotheSpecialIssueAchievingCarbonNeutralityinUrbanInfrastructureDevelopment)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---FigureA114pes,869KiB OpenAccessReviewNuclearMneticResonance(NMR)Metabolomics:CurrentApplicationsinEquineHealthAssessmentbyFulvioLaus,MarilenaBazzano,AndreaSpaterna,LucaLhiandAndreaMarchegianiMetabolites2024,14(5),269;doi.org/10.3390/metabo(registering DOI)-07May2024AbstractMetabolomicscanallowforthecomprehensiveidentificationofmetaboliteswithinbiologicalsystems,atgiventimepoints,inphysiologicalandpathologicalconditions.Inthelastfewyears,metabolomicanalysishasgainedpopularitybothinhumanandinveterinarymedicine,showinggreatpotentialfornovel[...]Readmore.Metabolomicscanallowforthecomprehensiveidentificationofmetaboliteswithinbiologicalsystems,atgiventimepoints,inphysiologicalandpathologicalconditions.Inthelastfewyears,metabolomicanalysishasgainedpopularitybothinhumanandinveterinarymedicine,showinggreatpotentialfornovelapplicationsinclinicalactivity.Theaimofapplyingmetabolomicsinclinicalpracticeisunderstandingthemechanismsunderlyingpathologicalconditionsandtheinfluenceofcertainstimuli(i.e.,drugs,nutrition,exercise)onbodysystems,intheattemptofidentifyingbiomarkersthatcanhelpinthedinosisofdiseases.ProtonNuclearMneticResonancespectroscopy(1H-NMR)iswelltailoredtobeusedasananalyticalplatformformetabolites’detectionatthebaseofmetabolomicsstudies,duetominimalsamplepreparationandhighreproducibility.Inthismini-reviewarticle,thescientificproductionofNMRmetabolomicapplicationstoequinemedicineisexamined.Theresearchworksareverydifferentinmethodologyanddifficulttocompare.Studiesaremainlyfocusedonexercise,reproduction,andnutrition,otherthanrespiratoryandmusculoskeletaldiseases.Theailableinformationonthistopicisstillscant,butagreatercollectionofdatacouldallowresearcherstodefinenewreliablemarkerstobeusedinclinicalpracticefordinosticandtherapeuticalpurposes.Fullarticle(ThisarticlebelongstotheSpecialIssueMetabolomicProfilinginEquineMedicineandReproduction)9658;9660;ShowFiguresFigure118pes,683KiB OpenAccessArticleSubtlePatternsofAlteredResponsivenesstoDelayedAuditoryFeedbackduringFingerTappinginPeopleWhoStutterbyGiorgioLazzari,RobertvandeVorst,FlorisT.vanVugtandCarlottaLegaBrainSci.2024,14(5),472;doi.org/10.3390/brainsci(registering DOI)-07May2024AbstractDifferencesinsensorimotorintegrationmechanismshebeenobservedbetweenpeoplewhostutter(PWS)andcontrolswhodonot.Delayedauditoryfeedback(DAF)introducestimingdiscrepanciesbetweenperceptionandaction,disruptingsequenceproductioninverbalandnon-verbaldomains.WhileDAFconsistentlyenhancesspeechfluency[...]Readmore.Differencesinsensorimotorintegrationmechanismshebeenobservedbetweenpeoplewhostutter(PWS)andcontrolswhodonot.Delayedauditoryfeedback(DAF)introducestimingdiscrepanciesbetweenperceptionandaction,disruptingsequenceproductioninverbalandnon-verbaldomains.WhileDAFconsistentlyenhancesspeechfluencyinPWS,itsimpactonnon-verbalsensorimotorsynchronizationabilitiesremainsunexplored.Atotalof11PWSand13matchedcontrolscompletedfivetasks:(1)unpacedtapping;(2)synchronization-continuationtask(SCT)withoutauditoryfeedback;(3)SCTwithDAF,withinstructioneithertoalignthesoundintimewiththemetronome;or(4)toignorethesoundandaligntheirphysicaltaptothemetronome.Additionally,wemeasuredparticipants’sensitivitytodetectingdelayedfeedbackusinga(5)delaydiscriminationtask.ResultsshowedthatDAFsignificantlyaffectedperformanceincontrolsasafunctionofdelayduration,despitebeingirrelevanttothetask.Conversely,PWSperformanceremainedstableacrossdelays.Whenauditoryfeedbackwasabsent,nodifferenceswerefoundbetweenPWSandcontrols.Moreover,PWSwerelessabletodetectdelaysinspeechandtappingtasks.Thesefindingsshowsubtledifferencesinnon-verbalsensorimotorperformancebetweenPWSandcontrols,specificallywhenaction–perceptionloopsaredisruptedbydelays,contributingtomodelsofsensorimotorintegrationinstuttering.Fullarticle(ThisarticlebelongstotheSpecialIssueBehioralandNeuralMechanismsUnderlyingSensory–MotorIntegration)13pes,866KiB OpenAccessArticleEfficacyofaLidocaine-ImpregnatedElastratorBandforCastrationandTailDockinginLambsbyStevenM.Roche,BrendaJ.Ralston,BarbaraOlson,BrendanD.Sharpe,CrystalSchatz,KendallBeaugrand,JosephA.Ross,MadeleineA.Broomfield,NicolasAllanandMerleOlsonAnimals2024,14(10),1403;doi.org/10.3390/ani(registering DOI)-07May2024AbstractTheprimaryobjectiveofthisstudywastodemonstratethenon-inferioritybetweenlidocaine-impregnatedligationbands(LLBs)andcontrolbands(CBs)withrespecttotheefficacyofcastrationandtaildocking.Secondaryobjectivesweretocomparecastrationandtail-dockingsuccess,evaluatelocalsitereactions,[...]Readmore.Theprimaryobjectiveofthisstudywastodemonstratethenon-inferioritybetweenlidocaine-impregnatedligationbands(LLBs)andcontrolbands(CBs)withrespecttotheefficacyofcastrationandtaildocking.Secondaryobjectivesweretocomparecastrationandtail-dockingsuccess,evaluatelocalsitereactions,andcompareeredailygain(ADG)betweenthetreatmentgroups.Atotalof238malelambswereenrolledandrandomlyassignedtoreceiveLLBsorCBsontheirtailandscrotum.Lambswereweighed,hadahealthassessment,andthebandsitewasobservedon−3,7,14,21,28,35,and42daysafterthebandswereapplied.Alinearregressionmodelwasbuilttoassesseredailygain,whereasarepeatedmeasuresmodelwasusedtoevaluatebodyweightdifferencesateachofthemeasuredtimepoints.Furthermore,logisticregressionmodelswereusedtoevaluateassociationswithcastingoutcomes.FewdifferenceswerenotedbetweentreatmentgroupswithrespecttocastingsuccessforthescrotumandtailandADGovertheentireexperimentalperiod.Non-inferioritycalculationsdemonstratednodifferencesintaildockingandscrotalcastingsuccess,withcastingoccurringforthemajorityofanimalsbyd21andd42forcastrationandtaildocking,respectively.However,lambsreceivingLLBsgainedmoreweightfromd−3to7(+0.03kg/d;95%CI:0to0.07),whichmaybeanindicationofeffectivepaincontrolduringthefirstweekfollowingbandapplication.Overall,theuseofanLLBdoesnotaffectthetimetosuccessfulcastingofthetailandcouldimproveshort-termgrowthwhencomparedtoacontrolband.FurtherstudiesareneededtocompareLLBstomultimodalmethodsofpainrelief.Fullarticle(ThisarticlebelongstotheSectionAnimalWelfare)9658;9660;ShowFiguresFigure1Figure2---Figure315pes,2952KiB OpenAccessArticleStudyonPreparationofCalcium-BasedModifiedCoalGangueandItsAdsorptionDyeCharacteristicsbyYihanWang,YanrongDong,JunliShao,ZilongZhaoandHongyuZhaiMolecules2024,29(10),2183;doi.org/10.3390/molecules(registering DOI)-07May2024AbstractEfficientandthoroughtreatmentofdyewastewaterisessentialtoachieveecologicalharmony.Inthisstudy,anewtypeofcalcium-basedmodifiedcoalgangue(Ca-CG)waspreparedbyusingsolidwastecoalgangueasrawmaterialandaCaCl2modifier,whichwas[...]Readmore.Efficientandthoroughtreatmentofdyewastewaterisessentialtoachieveecologicalharmony.Inthisstudy,anewtypeofcalcium-basedmodifiedcoalgangue(Ca-CG)waspreparedbyusingsolidwastecoalgangueasrawmaterialandaCaCl2modifier,whichwasusedfortheremovalofmalachitegreen,methyleneblue,crystalviolet,methylvioletandotherdyesinwater.WhenthedoseofCa-CGwas1–5g/L,thedoseofCa-CGwasthemainfactoraffectingthedyeadsorptioneffect.TheadsorptioneffectsofCa-CGonfourdyeswereasfollows:malachitegreen>crystalviolet>methyleneblue>methylviolet.Kinetics,isothermsandthermodynamicanalysisshowedthattheadsorptionofmalachitegreen,methylblue,crystalvioletandmethylvioletbyCa-CGfittedthesecond-orderkineticmodel,andadsorptionwithchemicalreactionisthemainprocess.TheadsorptionoffourdyesbyCa-CGconformedtotheFreundlichmodel,whichisdominatedbymulti-molecularlayeradsorption,andtheadsorptionwaseasytocarryout.TheadsorptionprocessofCa-CGonthefourdyeswasspontaneous.TheresultsofFTIR,XRDandSEMshowedthatthecalcium-basedmaterialssuchaslipscombiteanddolomitewerethekeytotheadsorptionofmalachitegreenbyCa-CG,andthemainmechanismsfortheadsorptionofmalachitegreenbyCa-CGaresurfaceprecipitation,electrostaticaction,andchelationreaction.Ca-CGadsorptionhasgreatpotentialfortheremovalofdyewastewater.Fullarticle(ThisarticlebelongstotheSpecialIssuePolymersBasedMaterialsforWaterTreatment)14pes,1047KiB OpenAccessReviewTheRoleofPOCUStoFaceCOVID-19:ANarrativeReviewbyStefanoSartini,LorenzoFerrari,OmbrettaCutuli,LucaCastellani,MariaLuisaCristina,EleonoraArboscelloandMarinaSartiniJ.Clin.Med.2024,13(10),2756;doi.org/10.3390/jcm(registering DOI)-07May2024AbstractCOVID-19hasbeenachallengingoutbreaktoface,withmillionsofdeathsamongtheglobe.Acuterespiratoryfailureduetointerstitialpneumoniawastheleadingcauseofdeathotherthanprothromboticactivationandcomplications.Lungultrasound(LUS)andpoint-of-careultrasound(POCUS)arewidely[...]Readmore.COVID-19hasbeenachallengingoutbreaktoface,withmillionsofdeathsamongtheglobe.Acuterespiratoryfailureduetointerstitialpneumoniawastheleadingcauseofdeathotherthanprothromboticactivationandcomplications.Lungultrasound(LUS)andpoint-of-careultrasound(POCUS)arewidelyusednotonlytotrie,toidentify,andtomonitorlungsinvolvementbutalsotoassesshemodynamicstatusandthromboticandhemorrhiccomplications,mainlyincriticallyillpatients.POCUShasgainedgrowingconsiderationduetoitsbedsideutilization,reliability,andreproducibilityeveninemergencysettingsespeciallyinunstablepatients.Inthisnarrativereview,weaimtodescribeLUSandPOCUSutilizationinCOVID-19infectionbaTafadhali subiri… Kivulisedontheliteraturefoundonthistopic.WereportedtheLUSpatternsofCOVID-19pulmonaryinfection,thedinosticaccuracywithrespecttoCTlungscan,itsprognosticvalue,thevarietyofscoresandprotocolsproposed,andtheutilizationofPOCUStoinvestigatetheextra-lungcomplications.Fullarticle(ThisarticlebelongstotheSectionPulmonology)24pes,8168KiB OpenAccessArticleOverestimatedFog-TopEntrainmentinWRFSimulationLeadingtoUnrealisticDissipationofSeaFog:ACaseStudybyLiZhang,HaoShi,ShanhongGaoandShunLiRemoteSens.2024,16(10),1656;doi.org/10.3390/rs(registering DOI)-07May2024AbstractEntrainmentatthetopoftheplanetaryboundarylayer(PBL)isofsignificantimportancebecauseitcontrolstheupwardgrowthofthePBLheight.Anoptioncalledysu_topdown_pblmix,whichprovidesaparameterizationoffog-topentrainment,hasbeenproposedforvalleyfogmodelingand[...]Readmore.Entrainmentatthetopoftheplanetaryboundarylayer(PBL)isofsignificantimportancebecauseitcontrolstheupwardgrowthofthePBLheight.Anoptioncalledysu_topdown_pblmix,whichprovidesaparameterizationoffog-topentrainment,hasbeenproposedforvalleyfogmodelingandintroducedintotheYSU(YonseiUniversity)PBLschemeintheWeatherResearchandForecasting(WRF)model.However,enablingthisoptioninsimulationsofseafogovertheYellowSeatypicallyresultsinunrealisticdissipationnearthefogbottomandevenwithintheentirefoglayer.Inthisstudy,wetheoreticallyexaminethecompositionoftheoptionysu_topdown_pblmix,andthenarguethatoneterminthisoptionmightberedundantforsea-fogmodeling.Thefog-topvariablesareemployedinthistermtodeterminethebasicentrainmentinthedryPBL,whichisalreadyparameterizedbythesurfacevariablesintheoriginalYSUPBLscheme.Thistermlikelyleadstoanoverestimationofthefog-topentrainmentrate,sowerefertoitasredundant.Toexploretheconnectionbetweentheredundanttermandunrealisticdissipation,awidespreadsea-fogepisodeovertheYellowSeaisemployedasacasestudybasedontheWRFmodel.Thesimulationresultsclearlyattributetheunrealisticdissipationtotheextraentrainmentratethattheredundantterminduces.Fog-topentrainmentisunexpectedlyoverestimatedduetothisextraentrainmentrate,resultinginasignificantlydrierandwarmerbiaswithintheinteriorofseafog.Whenseafogdevelopsandreachesatemperaturelowerthantheseasurface,theseasurfacefunctionsasawarmingsourcetoheatthefogbottomjointlywiththedownwardheatfluxbroughtbythefog-topentrainment,leadingthedissipationtoinitiallyoccurnearthefogbottomandthengraduallyexpandupwards.Wesuggestastraightforwardmethodtomodifytheoptionysu_topdown_pblmixforsea-fogmodelingthateliminatestheredundantterm.Theimprovementeffectofthismethodwassupportedbytheresultsofsensitivitytests.However,moresea-fogcasesarerequiredtovalidatethemodificationmethod.Fullarticle(ThisarticlebelongstotheSpecialIssueSevereWeatherObservationsandMeteorologyModelingDevelopmentUsingRemoteSensing)24pes,1491KiB OpenAccessArticleCollaborationtoAddresstheChallengesFacedbySmallholdersinPracticingOrganicriculture:ACaseStudyoftheOrganicSorghumIndustryinZunyiCity,ChinabyShengWuandShanweiLiriculture2024,14(5),726;doi.org/10.3390/riculture(registering DOI)-07May2024AbstractInmanydevelopingcountries,organicricultureisincreasinglyrecognizedasakeystrategyforpromotingruraleconomicdevelopmentandimprovingfarmerwelfare.Itisprimarilysmallholderswhoformthefoundationoforganicproductionintheseareas.However,thesefarmersfacesignificantchallengesin[...]Readmore.Inmanydevelopingcountries,organicricultureisincreasinglyrecognizedasakeystrategyforpromotingruraleconomicdevelopmentandimprovingfarmerwelfare.Itisprimarilysmallholderswhoformthefoundationoforganicproductionintheseareas.However,thesefarmersfacesignificantchallengesinadoptingorganicfarmingmethods.Theaimofthispaperistoinvestigatesolutionstothechallengesencounteredbysmallholders.ThisresearchutilizesanintegratedapproachandincludesacasestudyoftheorganicsorghumsectorinZunyi,China.Thefindingsindicatethat(1)arobustpartnershiphasbeenestablishedbetweenenterprises,government,andfarmersintheorganicsorghumindustryinZunyi.Enterprisespurchasethesorghum,coverorganiccertificationcosts,andpartiallyfundmaterialinputs,whilelocalgovernmentfacilitatesorganization,coordination,andtechnicalsupport,withfarmersresponsibleforproduction.(2)Thiscollaborationhascatalyzedhigh-qualitydevelopmentintheindustry,benefitingallstakeholders.(3)Throughthiscollaborativemodel,commonchallengesfacedbysmallholders,suchasobstaclesinobtainingcertification,incomefluctuations,andunfairmarketconditions,hebeenmitigated.Consequently,smallholderssecurestableandreliableincomeastheybenefitfromforablecontractpricesfororganicsorghumandtheassumptionbyenterprisesofmostmaterialinputcosts.Thisstudyoffersvaluableempiricalevidencethatcanguidetheexpansionoforganicricultureinsimilarregionsandcountries.Fullarticle(ThisarticlebelongstotheSectionriculturalEconomics,PoliciesandRuralManement)9pes,905KiB OpenAccessArticleTheRelationshipbetweenFrontalQRS-TAngleandVitaminDDeficiencybyFulyacıDemir,GülsümBingöl,İbrahimErsoy,AkifArslan,PınarErsoy,MeltemDemirandSerkanÜnlüMedicina2024,60(5),776;doi.org/10.3390/medicina(registering DOI)-07May2024AbstractBackgroundandObjectives:Adeficiencyinserum25-hydroxyvitaminDlevelsisassociatedwithanumberofcardiovascularsituations,suchashighbloodpressure,heartfailure,atheroscleroticheartdisease,andperipheralarterydisease.ThefrontalQRS-Tanglehasrecentlybeenproposedasa[...]Readmore.BackgroundandObjectives:Adeficiencyinserum25-hydroxyvitaminDlevelsisassociatedwithanumberofcardiovascularsituations,suchashighbloodpressure,heartfailure,atheroscleroticheartdisease,andperipheralarterydisease.ThefrontalQRS-Tanglehasrecentlybeenproposedasamarkerofventricularrepolarization.AwiderfrontalQRS-Tanglehasbeenpositivelycorrelatedwithadversecardiacevents.Theobjectiveofourstudywastoexaminetheassociationbetweenserum25-hydroxyvitaminDlevelandthefrontalQRS-Tangle.MaterialsandMethods:Atotalof173consecutivepatientsed18–60yearsundergoingroutinecardiologycheck-upevaluation,andnotreceivingconcurrentvitaminDtreatmentwereincludedinthestudy.Patientswereclassifiedinthreegroups,dependingontheirvitaminDlevels,andcategorizedasfollows:Group1—deficient(<20ng/mL),Group2—insufficient(20–29ng/mL),orGroup3—optimal(≥30ng/mL).ThefrontalQRS-Tanglewasdeterminedusingtheautomatedreportsgeneratedbytheelectrocardiographymachine.Results:Theereeofparticipantswas45.8(±12.2)years,and55.5%ofparticipantswerefemale(p<0.001).IndividualswithlowvitaminDconcentrationsexhibitedawiderfrontalQRS-Tangle.ItwasdeterminedthatvitaminDlevelisanindependentpredictivefactorforthefrontalQRS-Tangle.Conclusions:Asthelevelsof25-hydroxyvitaminDdecrease,repolarizationtimeassessedbyfrontalQRS-Tangleiswidened.OurfindingsindicatethatlowerconcentrationsofvitaminDmayincreasethesusceptibilitytoventriculararrhythmia.Fullarticle(ThisarticlebelongstotheSpecialIssueInsightsintoCardiovascularDiseases)9658;9660;ShowFiguresFigure1attachmentSupplementarymaterial:SupplementaryFile1(ZIP,115KiB)17pes,521KiB OpenAccessArticleAHigherAdherencetotheALINFANutritionalInterventionIsEffectiveforImprovingDietaryPatternsinChildrenbyNataliaVázquez-Bolea,NaroaAndueza,MartaCuervoandSantioNas-CarreteroChildren2024,11(5),559;doi.org/10.3390/children(registering DOI)-07May2024AbstractFoodpatternsaredeterioratingand,consequently,notmeetingnutritionalrecommendations.Learningabouttheadherencetoadietiscrucialforunderstandingchildren’sdietaryhabits.TheobjectiveofthepresentanalysiswastoassessthedegreeofcompliancewiththeALINFAnutritionalinterventionand[...]Readmore.Foodpatternsaredeterioratingand,consequently,notmeetingnutritionalrecommendations.Learningabouttheadherencetoadietiscrucialforunderstandingchildren’sdietaryhabits.TheobjectiveofthepresentanalysiswastoassessthedegreeofcompliancewiththeALINFAnutritionalinterventionandtheeffectivenessofadherencegroups,andtoevaluatepotentialbaselinefactorspredictingahigheradherencetotheintervention.Atotalof44childrened6to12years-oldparticipatedintheeight-weekintervention.Atwo-weekdietaryplanwasspecificallydesigned,providingparticipantswithfoodproducts,ready-to-eatdishes,andrecipes.Anintakeof75%ofcaloriesoftheprescribeddietwasdefinedtodividetheparticipantsintohigh-andlow-adherencegroups(HA/LA,respectively).Fromthe44participants,24showedaLAtotheintervention,whereas20ofthemwereintheHAgroup.Dietqualityimprovedinbothgroups(p<0.001),mainlybyincreasingcerealsandnuts,andreducingpastries.AdecreaseinBMIz-scorewasobserved(LA:p<0.001;HA:p=0.021).Fatmass(p=0.002),LDL-c(p=0.036),andCRP(p=0.023)reductionswereonlyachievedintheHAgroup,whereasleptindecreasedonlyintheLAgroup(p=0.046).Allparticipantsamelioratedtheirdietaryhabits,butthosewithbetterdietqualityatbaselineexperiencedgreaterenhancementsintheirnutritionalstatus.Fullarticle(ThisarticlebelongstotheSpecialIssueNutritiontoImproveChildandAdolescentHealth)9658;9660;ShowFiguresGraphicalabstract22pes,2459KiB OpenAccessArticleEnergyLoadForecastingTechniquesinSmartGrids:ACross-CountryComparativeAnalysisbyRachidaHachache,MouradLabrahmi,AntónioGrilo,AbdelaaliChaoub,RachidBennani,AhmedTamtaouiandBrahimLakssirEnergies2024,17(10),2251;doi.org/10.3390/en(registering DOI)-07May2024AbstractEnergymanementsystemsallowtheSmartGridsindustrytotrack,improve,andregulateenergyuse.Particularly,demand-sidemanementisregardedasacrucialcomponentoftheentireSmartGridssystem.Therefore,byaligningutilityofferswithcustomerdemand,anticipatingfutureenergydemandsis[...]Readmore.EnergymanementsystemsallowtheSmartGridsindustrytotrack,improve,andregulateenergyuse.Particularly,demand-sidemanementisregardedasacrucialcomponentoftheentireSmartGridssystem.Therefore,byaligningutilityofferswithcustomerdemand,anticipatingfutureenergydemandsisessentialforregulatingconsumption.Anupdatedexaminationofseveralforecastingtechniquesforprojectingenergyshort-termloadforecastsisprovidedinthisarticle.Eachclassofalgorithms,includingstatisticaltechniques,MachineLearning,DeepLearning,andhybridcombinations,arecomparativelyevaluatedandcriticallyanalyzed,basedonthreerealconsumptiondatasetsfromSpain,Germany,andtheUnitedStatesofAmerica.Toincreasethesizeoftinytrainingdatasets,thispaperalsoproposesadataaugmentationtechniquebasedonGenerativeAdversarialNetworks.TheresultsshowthattheDeepLearning-hybridmodelismoreaccuratethantraditionalstatisticalmethodsandbasicMachineLearningprocedures.Inthesamedirection,itisdemonstratedthatmorecomprehensivedatasetsassistedbycomplementarydata,suchasenergygenerationandweather,maysignificantlyboosttheaccuracyofthemodels.Additionally,itisalsodemonstratedthatGenerativeAdversarialNetworks-baseddataaugmentationmaygreatlyimprovealgorithmaccuracy.Fullarticle(ThisarticlebelongstotheSectionA1:SmartGridsandMicrogrids)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure67pes,903KiB OpenAccessOpinionSpecificExtracellularVesicles,GeneratedandOperatingatSynapses,ContributetoNeuronalEffectsandSignalingbyJacopoMeldolesiInt.J.Mol.Sci.2024,25(10),5103;doi.org/10.3390/ijms(registering DOI)-07May2024AbstractInallcelltypes,smallEVs,veryabundantextracellularvesicles,aregeneratedandaccumulatedwithinMVBendocyticcisternae.UponMVBfusionandexocytosiswiththeplasmamembrane,theEVsarereleasedtotheextracellularspace.Inthecentralnervoussystem,thereleaseof[...]Readmore.Inallcelltypes,smallEVs,veryabundantextracellularvesicles,aregeneratedandaccumulatedwithinMVBendocyticcisternae.UponMVBfusionandexocytosiswiththeplasmamembrane,theEVsarereleasedtotheextracellularspace.Inthecentralnervoussystem,thereleaseofneuronalEVswasbelievedtooccuronlyfromthesurfaceofthebodyanddendrites.About15yearso,MVBcisternaeandEVswereshowntoexistandfunctionatsynapticboutons,theterminals’pre-andpost-synapticstructuresessentialforcanonicalneurotransmitterrelease.RecentstudiesherevealedthatsynapticEVsarepeculiarinmanyrespectsandheterogeneouswithrespecttootherneuronalEVs.ThedistributionofsynapticEVsandtheeffectoftheirspecificmoleculesarefoundatcriticalsitesoftheirdistribution.TheroleofsynapticEVscouldconsistofthemodulationofcanonicalneurotransmitterreleaseoradistinct,non-canonicalformofneurotransmission.AdditionalrolesofsynapticEVsarestillnotcompletelyknown.Inthefuture,additionalinvestigationswillclarifytheroleofsynapticEVsinpathology,concerning,forexample,circuits,trans-synaptictransmission,dinosisandthetherapyofdiseases.Fullarticle(ThisarticlebelongstotheSpecialIssueExosomesandExtracellularVesiclesinHealthandDiseases2.0)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,222KiB)14pes,474KiB OpenAccessArticleComparativeAnalysisofResponsetoCardiacResynchronisationTherapyUpgradesinPatientswithImplantableCardioverter-DefibrillatorsandPacemakersbyArsalanFarhangee,MarkJ.Dies,MihaiMesina,DidRogerMorgan,BenjaminJ.Sieniewicz,RobynMeyrick,KatieGaughanandIonMîndrilăJ.Clin.Med.2024,13(10),2755;doi.org/10.3390/jcm(registering DOI)-07May2024AbstractIntroduction:Theefficacyofdenovocardiacresynchronisationtherapy(CRT)inpatientswithheartfailure(HF),leftventricularsystolicdysfunction(LVSD),andabroadQRSmorphologyiswellestablished.However,theoptimalsteforupgradingpatientswithexistingpacemakers(PPMs)orimplantablecardioverter-defibrillators[...]Readmore.Introduction:Theefficacyofdenovocardiacresynchronisationtherapy(CRT)inpatientswithheartfailure(HF),leftventricularsystolicdysfunction(LVSD),andabroadQRSmorphologyiswellestablished.However,theoptimalsteforupgradingpatientswithexistingpacemakers(PPMs)orimplantablecardioverter-defibrillators(ICDs)andHFwithhigh-burdenrightventricular(RV)pacingremainsuncertain.Thus,thismulticentreretrospectiveanalysiscomparedpatientswithpre-existingPPMsorICDswhounderwentCRTupgradestoinvestigatetheappropriatesteforCRTimplantationinthesepatientsandtoassessthevalidityoftreatingbothPPMandICDrecipientsunderthesamerecommendationlevelinthecurrentguidelines.MaterialsandMethods:Atotalof151participantsunderwentanalysisinthisstudy,comprising93upgradestocardiacresynchronisationtherapywithpacemaker(CRT-P)and58upgradestocardiacresynchronisationtherapywithdefibrillator(CRT-D)acrossthreecentresintheUK.TheaimofthestudywastoinvestigatethesafetyandefficacyofupgradingtoCRTfromanexistingconventionalpacemakeroranICDinthecontextofhigh-burdenRVpacing.Theanalysiswasconductedseparatelyforeachgroup,assessingchangesinechocardiographicparameters,functionalNewYorkHeartAssociation(NYHA)class,andprocedure-relatedcomplications.Results:ThePPMgrouphadahigherpercenteRVPburdencomparedtotheICDgroup.Post-upgrade,NYHAfunctionalclassandEFandLVvolumesimprovedinbothgroups;however,theresponsetoanupgradefromapacemakerwasgreatercomparedtoanupgradefromanICD.Post-proceduralcomplicationrisksweresimilaracrossthetwosubgroupsbutsignificantlyhighercomparedtodenovoimplantation.Conclusions:WithintheCRT-Psubgroup,participantsexhibitedbetterresponsesthantheirCRT-Dcounterparts,evidentbothinechocardiographicimprovementsandclinicaloutcomes.Furthermore,patientswithnon-ischemiccardiomyopathy(NICM)werebetterrespondersthanthosewithischaemiccardiomyopathy.Thesefindingssuggestthatinternationalguidelinesshouldconsiderapproachingeachsubgroupseparatelyinthefuture.Fullarticle(ThisarticlebelongstotheSpecialIssueBetterManementofHeartFailure:ContemporaryStrategyandFuturePerspective)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure414pes,613KiB OpenAccessArticleAutomaticEvaluationMethodforFunctionalMovementScreeningBasedonMulti-ScaleLightweight3DConvolutionandanEncoder–DecoderbyXiuchunLin,YichaoLiu,ChenFeng,ZhideChen,XuYangandHuiCuiElectronics2024,13(10),1813;doi.org/10.3390/electronics(registering DOI)-07May2024AbstractFunctionalMovementScreening(FMS)isatestusedtoevaluatefundamentalmovementpatternsinthehumanbodyandidentifyfunctionallimitations.However,thechallengeofcarryingoutanautomatedassessmentofFMSisthatcomplexhumanmovementsaredifficulttomodelaccuratelyand[...]Readmore.FunctionalMovementScreening(FMS)isatestusedtoevaluatefundamentalmovementpatternsinthehumanbodyandidentifyfunctionallimitations.However,thechallengeofcarryingoutanautomatedassessmentofFMSisthatcomplexhumanmovementsaredifficulttomodelaccuratelyandefficiently.Toaddressthischallenge,thispaperproposesanautomaticevaluationmethodforFMSbasedonamulti-scalelightweight3Dconvolutionencoder–decoder(ML3D-ED)architecture.Thismethodadoptsaself-builtmulti-scalelightweight3Dconvolutionarchitecturetoextractfeaturesfromvideos.Theextractedfeaturesarethenprocessedusinganencoder–decoderarchitectureandprobabilisticintegrationtechniquetoeffectivelypredictthefinalscoredistribution.Thisarchitecture,comparedwiththetraditionalTwo-StreamInflated3DConvNet(I3D)network,offersabetterperformanceandaccuracyincapturingadvancedhumanmovementfeaturesintemporalandspatialdimensions.Specifically,theML3D-EDbackbonenetworkreducesthenumberofparametersby59.5%andthecomputationalcostby77.7%whencomparedtoI3D.ExperimentsheshownthatML3D-EDachievesanaccuracyof93.33%onpublicdatasets,demonstratinganimprovementofapproximately9%overthebestexistingmethod.ThisoutcomedemonstratestheeffectivenessofandadvancemTafadhali subiri… KivulientsmadebytheML3D-EDarchitectureandprobabilisticintegrationtechniqueinextractingadvancedhumanmovementfeaturesandevaluatingfunctionalmovements.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinImeProcessingandComputerVisionBasedonMachineLearning)37pes,687KiB OpenAccessReviewInnovationsinWheatBread:UsingFoodIndustryBy-ProductsforBetterQualityandNutritionbyPiotrZarzycki,AnnaWirkijowska,DorotaTeteryczandPaulinaŁysakowskaAppl.Sci.2024,14(10),3976;doi.org/10.3390/app(registering DOI)-07May2024AbstractTheevolutionofwheatbreadasadietarystapleunderscoresitsessentialroleinprovidingenergy,protein,fiber,andvitalnutrients.Toaddresscontemporaryhealthchallengessuchastype2diabetesandcardiovasculardiseases,fortifyingwheatbreadwithhealth-promotingadditivesbecomesimperativeto[...]Readmore.Theevolutionofwheatbreadasadietarystapleunderscoresitsessentialroleinprovidingenergy,protein,fiber,andvitalnutrients.Toaddresscontemporaryhealthchallengessuchastype2diabetesandcardiovasculardiseases,fortifyingwheatbreadwithhealth-promotingadditivesbecomesimperativetomitigatedeficienciesresultingfromrefinedwheatflourconsumption.Functionalfoodinnovations,alignedwithsustainabilitygoalsandcirculareconomyprinciples,offerpromisingapproachesforaddressingtheseconcerns.Integratingby-productsfromfruitsandoilcropsintobreadformulationsenhanceshealthbenefitsbyboostingdietaryfiber,bioactivecompounds,andantioxidantpotential.However,gapspersistinunderstandinganti-nutritionalsubstancesandcontaminantsinfinalproducts,necessitatingfurtherresearchforcomprehensivesafetyassessments.Theadditionofby-productrawmaterialssignificantlyinfluencesdoughrheologyandsensorycharacteristics,potentiallyachievingqualitycomparabletotraditionalwheatbread.Challengesincludeinconsistenciesinbreadandby-productspecificationsacrossstudies,hinderingdirectresultcomparison.Overcomingtheseobstaclesiscrucialformaximizingthepotentialofri-foodby-productsincreatinghealthier,sustainablebreadoptionswhilemaintainingsafetyandqualitystandards.Fullarticle(ThisarticlebelongstotheSpecialIssueFunctionalBakeryProducts:Technological,ChemicalandNutritionalModification)MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEngEngineeringProceedingsEntropyEnvironmentalSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFireFishesFluidsFoodsForecastingForensicSciencesForestsFossilStudiesFoundationsFractalandFractional(FractalFract)FuelsFutureFutureInternetFuturePharmacologyFutureTransportationGalaxiesGamesGasesGastroenterologyInsightsGastrointestinalDisordersGastronomyGelsGenealogyGenesGeographiesGeoHazardsGeomaticsGeosciencesGeotechnicsGeriatricsGlaciesGout,Urate,andCrystalDepositionDisease(GUCDD)GrassesHardwareHealthcareHeartsHematoHematologyReportsHeriteHistoriesHorticulturaeHospitalsHumanitiesHumansHydrobiologyHydrogenHydrologyHygieneImmunoInfectiousDiseaseReportsInformaticsInformationInfrastructuresInorganicsInsectsInstrumentsInternationalJournalofEnvironmentalResearchandPublicHealth(IJERPH)InternationalJournalofFinancialStudies(IJFS)InternationalJournalofMolecularSciences(IJMS)InternationalJournalofNeonatalScreening(IJNS)InternationalJournalofPlantBiology(IJPB)InternationalJournalofTopologyInternationalJournalofTranslationalMedicine(IJTM)Internation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